HEAD OF LRU CRITICAL CARE
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PROF. DR. MED.
ALBERTO PAGNAMENTA

DEPUTY HEAD INTENSIVE CARE UNIT
+41 (0)91 811 64 82

Steering Committee

  • Prof. Dr. med. Paolo Merlani: Head DAC OCL, Lugano
  • Dr med. Michael Llamas, Head DAC ODL, Locarno
  • Prof. Dr. med. Andreas Perren, Head DAC ORBV, Bellinzona
  • Dr med. Marco Grischott, Head DAC OBV, Mendrisio
  • PD Dr. med. Andrea Saporito: Head Anesthesiology, ORBV Bellinzona
  • Dr. med. Laura Uccella: Senior physician, Emergency Department (ED), OCL Lugano
  • Loris Bonetti, RN PhD: Head Nursing Research Competence Centre, EOC Bellinzona
  • Prof. Dr. med. Alberto Pagnamenta
RESEARCH AREA AND MAIN RESEARCH INTERESTS/TOPICS

The Department of Anesthesiology, Emergency and Intensive Care Medicine of the Ente Ospedaliero Cantonale (“Dipartimento Area Critica”: DAC-EOC) is a functional Department. Each of the four public hospitals of the EOC has his own DAC. The four local DACs make up the DAC-EOC. Each local DAC is headed by a local Director. The DAC-EOC coordinates and facilitates the integration and the collaboration among the four local DACs for patients’ care, innovation and for research purposes. The DAC-EOC is responsible for the didactic module “Critical Care Medicine” for the Medical Master School (third semester) of the Faculty of Biomedical Sciences of the Università della Svizzera italiana (USI). Furthermore, it supports medical students for their master’s and/or doctoral thesis. In 2022 a Local Research Unit (LRU) for the entire DAC-EOC has been established and headed by a staff physician of the Department. The Steering Committee of the LRU of the DAC-EOC includes the four Directors of the local DACs and one representative per specialty. The main aim of the LRU is to support any researcher/investigator from study conception to manuscript submission in peer review journals. Each specialty: Anesthesiology, Emergency Medicine and Intensive Care Medicine manage their own research projects as both monocentric and multicentric trials in collaboration with other Swiss and foreign research centers. We support nursing research, in accordance with the Swiss Society of Intensive Care Medicine, which is the only nursing/medical society in Switzerland. Our LRU is not responsible for the fundraising of the DAC. One of the purposes of the LRU of the DAC-EOC is to encourage common projects among the different Services of the Department and especially regarding the transition of care (interdisciplinary and interprofessional projects). Quality-improvements studies and especially process-improvements trials are still scarce in medicine and especially in the acute care setting.

 

Different topics are currently investigated by the DAC-EOC, and thereafter we mention the most relevant:

 

  • Diagnostic accuracy of Point of Care Ultrasound in different clinical settings, especially in Anesthesiology and Intensive Care Medicine
  • Cost-effectiveness analysis in Anesthesiology
  • Perioperative transfusion’s strategies
  • Use of different analgetic regimen and analgetic procedures in the post-operative setting
  • Treatment strategies for chronic pain syndromes
  • Impact of the COVID-19 pandemic on the occurrence of different complications (herpes simplex recurrence) in the ICU population
  • Best practice for the care of mild traumatic brain injury in the Emergency Department (ED)
  • Communication practices in the ED for outpatients

 

Different projects are working in progress. Here a selection of the most promising: optimization of the time to transfer for patients from the ED to the ICU and identification of barriers; use of artificial intelligence and machine learning techniques for the early identification of nosocomial infections; strategies to improve communication’s skills of ED doctors; impact of delayed transfer of patients from the ward to the ICU.

PUBLICATIONS
  • Amati M, Valnegri A, Bressan A, La Regina D, Tassone C, Lo Piccolo A, Mongelli F, Saporito A. Reducing Changeover Time Between Surgeries Through Lean Thinking: An Action Research Project. Front Med (Lausanne). 2022;9:822964. IF 5.058, Q2, PMID 35573003
  • Berli S, Brandi G, Keller E, Najia N, Vitale J, Pagnamenta A. Clinical efficacy of the enzyme replacement therapy in patients with late-onset Pompe disease: a systematic review and a meta-analysis. J Neurol. 2022;269:733-41. IF 6.682, Q1, PMID 33851281
  • Biasco L, Valotta A, Klersy C, Valgimigli M, Gabutti L, Bruna RD, Pagnamenta A, Ruinelli L, Senatore G, Pedrazzini GB. Association among myocardial injury and mortality in Influenza: A prospective cohort study. Int J Cardiol. 2022;369:48-53. IF 4.039, Q2, PMID 35944772
  • Ceruti S, Dell’Era S, Ruggiero F, Bona G, Glotta A, Biggiogero M, Tasciotti E, Kronenberg C, Lollo G, Saporito A. Nasogastric tube in mechanical ventilated patients: ETCO2 and pH measuring to confirm correct placement. A pilot study. PLoS One. 2022;17:e0269024. IF 3.752, Q2, PMID 35653380
  • Czarnetzki C, Albrecht E, Desmeules J, Kern C, Corpataux JB, Gander S, van Kuijk SMJ, Tramèr MR. Dexamethasone for the treatment of established postoperative nausea and vomiting: A randomised dose finding trial. Eur J Anaesthesiol. 2022;39:549-57. IF 4.183, Q2, PMID 34799501
  • Dongelmans DA, Quintairos A, Buanes EA, Aryal D, Bagshaw S, Bendel S, Bonney J, Burghi G, Fan E, Guidet B, Haniffa R, Hashimi M, Hashimoto S, Ichihara N, Vijayaraghavan BKT, Lone N, Del Pilar Arias Lopez M, Mazlam MZ, Okamoto H, Perren A, Rowan K, Sigurdsson M, Silka W, Soares M, Viana G, Pilcher D, Beane A, Salluh JIF. Worldwide clinical intensive care registries response to the pandemic: An international survey. J Crit Care. 2022;71:154111. IF 4.298, Q2, PMID 35816947
  • Gloor Y, Czarnetzki C, Curtin F, Gil-Wey B, Tramèr MR, Desmeules JA. Genetic Susceptibility Toward Nausea and Vomiting in Surgical Patients. Front Genet. 2021;12:816908. IF 4.772, Q1, PMID 35173765
  • Iattoni M, Ormazabal M, Luvini G, Uccella L. Effect of Structured Briefing Prior to Patient Arrival on Interprofessional Communication and Collaboration in the Trauma Team. Open Access Emerg Med. 2022;14:385-93. IF n/a, PMID 35936514
  • Leo M, Galante A, Pagnamenta A, Ruinelli L, Ponziani FR, Gasbarrini A, De Gottardi A. Hepatocellular liver injury in hospitalized patients affected by COVID-19: Presence of different risk factors at different time points. Dig Liver Dis. 2022;54:565-71. IF 5.165, Q2, PMID 35093272
  • Marando M, Fusi-Schmidhauser T, Tamburello A, Grazioli Gauthier L, Rigamonti E, Argentieri G, Puligheddu C, Pagnamenta A, Valenti A, Pons M, Gianella P. 1-year radiological, functional and quality-of-life outcomes in patients with SARS-CoV-2 pneumonia – A prospective observational study. NPJ Prim Care Respir Med. 2022;32:8. IF 3.289, Q2, PMID 35241685
  • Petrino R, Riesgo LG, Yilmaz B. Burnout in emergency medicine professionals after 2 years of the COVID-19 pandemic: a threat to the healthcare system? Eur J Emerg Med. 2022;29:279-84. IF 4.106, Q1, PMID 35620812
  • Previsdomini M, Colombo J, Cerutti B, Gerber B, Hofmann A, Chiesa AF, Saporito A, La Regina D, Cafarotti S, Patella M, Perren A. Dissemination of patient blood management practices in Swiss intensive care units: a cross-sectional survey. Swiss Med Wkly. 2022;152:w30184. IF 4.203, Q2, PMID 35752954
  • Prodi E, Danieli L, Manno C, Pagnamenta A, Pravatà E, Roccatagliata L, Städler C, Cereda CW, Cianfoni A. Stroke Mimics in the Acute Setting: Role of Multimodal CT Protocol. AJNR Am J Neuroradiol. 2022;43:216-22. IF 4.966, Q2, PMID 34969667
  • Riegger M, Müller J, Giampietro A, Saporito A, Filardo G, Treglia G, Guidi M, Candrian C. Forefoot Adduction, Hindfoot Varus or Pes Cavus: Risk Factors for Fifth Metatarsal Fractures and Jones Fractures? A Systematic Review and Meta-Analysis. J Foot Ankle Surg. 2022;61:641-7. IF 1.345, Q4, PMID 35039196
  • Saporito A, La Regina D, Hofmann A, Ruinelli L, Merler A, Mongelli F, Trentino KM, Ferrari P. Perioperative inappropriate red blood cell transfusions significantly increase total costs in elective surgical patients, representing an important economic burden for hospitals. Front Med (Lausanne). 2022;9:956128. IF 5.058, Q2, PMID 36111110
  • Torre A, Marengo M, Ledingham NS, Ajani C, Volontè F, Garofalo F, Mongelli F. Opioid-Free Anesthesia in Bariatric Surgery: a Propensity Score-Matched Analysis. Obes Surg. 2022;32:1673-80. IF 3.479, Q2, PMID 35294692
  • Uccella S, Mongelli F, Majno-Hurst P, Pavan LJ, Uccella S, Zoia C, Uccella L. Psychological Impact of the Very Early Beginning of the COVID-19 Outbreak in Healthcare Workers: A Bayesian Study on the Italian and Swiss Perspectives. Front Public Health. 2022;10:768036. IF 6.461, Q1, PMID 35400074
  • Zaffina C, Wyttenbach R, Pagnamenta A, Grasso RF, Biroli M, Del Grande F, Rizzo S. Body composition assessment: comparison of quantitative values between magnetic resonance imaging and computed tomography. Quant Imaging Med Surg. 2022;12:1450-66. IF 4.630, Q2, PMID 35111638
  • Karim HM, Šarc I, Calandra C, Spadaro S, Mina B, Ciobanu LD, Gonçalves G, Caldeira V, Cabrita B, Perren A, Fiorentino G, Utku T, Piervincenzi E, El-Khatib M, Alpay N, Ferrari R, Abdelrahim ME, Saeed H, Madney YM, Harb HS, Vargas N, Demirkiran H, Bhakta P, Papadakos P, Gómez-Ríos M, Abad A, Alqahtani JS, Hadda V, Singha SK, Esquinas AM. Role of Sedation and Analgesia during Noninvasive Ventilation: Systematic Review of Recent Evidence and Recommendations. Indian J Crit Care Med. 2022;26:938-48. IF n/a, PMID 36042773
  • Petrino R, Castrillo LG, Yilmaz B, Dodt C, Tuunainen E, Khoury A. Policy statement on minimal standards for safe working conditions in Emergency Medicine. Eur J Emerg Med. 2022;29:389-90. IF 4.106, Q1, PMID 36243015
  • Czarnetzki C. In Response. Anesth Analg. 2022;134:e37-e8. IF 6.627, Q1, PMID 35595702
FINANCIAL SUPPORT
  • Non competitive and competitive Swiss and foreign Grants